Computational biology × AI safety and evaluation

Evidence infrastructure for biological AI.

I build benchmarks and reproducible systems that test whether models ground specialist outputs, allocate verification where it matters, generalize across real biological data, and stay calibrated when those outputs reach a real laboratory.

Senior Research Associate and Director for Spaceflight · Mason Lab, Weill Cornell Medicine

Selected work

Capability, measured. Failure, reported.

Seven public projects spanning model grounding, verification-aware agents, mission-shift generalization, drug-discovery decisions, laboratory execution, evidence across agent handoffs, and safeguard calibration. Each links claims to inspectable code, data, or result artifacts.

PROJECT 01Grounding

grounding-atlas

A measurement-first map of whether language models ground the content of biological representations—sequence, structure, identifiers, and numeric predictions—or rely on labels and familiarity. It connects measured gaps to a practical train, retrieve, or orchestrate decision map.

17 representations studied24 GroundBench tasks9 modalitiesGPU-free output harness
PROJECT 02Verification

Verify-or-Trust

A verifiable-reward benchmark for a central agentic decision: when a biology foundation model may be wrong, should the agent trust it or spend budget on a real differential-expression assay?

Held-out perturb-seq truthReal DE tool107-panel studyLLM-free baselines
PROJECT 03Space biology

SpaceBio-Bench

Mission-held-out transcriptomics benchmarks for a hard biological generalization question: can a model trained on one spaceflight study recognize a signal in a mission it has never seen?

NASA OSDR data8 tissuesMission-held-out splitsPublic fold package
PROJECT 04Agent systems

Agentic Drug Discovery System

An auditable clinical and regulatory decision benchmark with callable data adapters, verifier contracts, an installable scorer, and reproducible clinical-trial decision labels.

Source-derived labelsTool adaptersVerifier contractsInstallable scorer

Current scope: a retrospective benchmark plus one audited end-to-end disease slice—not a finished eight-stage discovery platform.

PROJECT 05Agent evaluation

LabCraft-Eval

An Inspect AI environment that evaluates agents executing benign molecular-microbiology protocols inside a seeded stochastic simulator, with deterministic four-axis trajectory scoring.

Seeded simulatorTrajectory-level scoringInspect AIProvenance-checked export
PROJECT 06Agent safety

Scientific Agent Verification Cascade

A prespecified test of whether scientific evidence survives handoffs between agents, or whether the last agent in a chain ends up citing its predecessor instead of the original source, and how far a structured claim record and a runtime gate recover what is lost.

Prespecified protocolTwo model familiesMatched single-agent controlsStructured claim records
PROJECT 07Safeguard calibration

Safeguard Calibration Study

A controlled study of whether safeguards stay calibrated when the same science changes form, moving across names, database identifiers, sequences and annotations, and when delivery moves from a chat window to a tool call. Released with an outcomes-only public dataset.

Matched task controlsCross-version comparisonOutcomes-only public dataDocumented claim reconciliation

Research program

Biology is the test bed.

My evaluation work is grounded in computational biology: human spaceflight multi-omics, single-cell and spatial genomics, perturb-seq, and the practical constraints of scientific workflows.

Featured benchmark

SpaceOmicsBench

A multi-omics AI benchmark built from public spaceflight biomedical releases across Inspiration4, the NASA Twins Study, and JAXA Cell-Free Epigenome data.

21ML tasks
9modalities
100LLM questions

How I work

From biological question to auditable artifact.

  • Define the independence unit before choosing a split or metric.
  • Use domain evidence and real tools instead of answer-only judging where possible.
  • Separate deterministic value proofs from stochastic model runs.
  • Publish provenance, limitations, and machine-readable release surfaces with the result.

Research foundation

Depth in biology. Range in AI.

I serve as Senior Research Associate and Director for Spaceflight in the Mason Lab at Weill Cornell Medicine, where I connect biomedical discovery with rigorous AI evaluation.

60+publications and scholarly outputs
14first or co-first author, 10 in the Nature Portfolio, one co-corresponding
100+SOMA investigators
24+countries in the SOMA network
2026

Coefficient Giving Career Development and Transition Funding

Individual scholarship supporting a transition into AI-bio safety research.

2026

Anthropic AI for Science Program

Compute support for research on evidence-aware biological language models.

2026

NSF ACCESS Explore Allocation

Principal investigator allocation for scalable computational research.

2024

Humans In Space Challenge

Orbital launch funding for spaceflight biomedical research.

Connect

Building better evidence for biological AI.

Open to research conversations across AI for science, evaluation, post-training, and computational biology.

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